Phosphonate-nucleotide ester derivatives

ABSTRACT

Phosphonate-nucleotide ester compounds of the formula (I) have excellent antiviral activity and antineoplastic activity. Further, they can be orally administered. ##STR1## wherein ring A represents ##STR2## wherein R 1  and R 2  independently represent hydrogen, halogen, hydroxyl, mercapto, C 6  -C 10  arylthio or amino; R 3  represents C 1  -C 4  alkyl or ethyl having one or more substituents selected from the group consisting of fluorine, C 1  -C 4  alkoxy, phenoxy, C 7  -C 10  phenylalkoxy and C 2  -C 5  acyloxy; R 4  represents ethyl having one or more substituents selected from the group consisting of fluorine, C 1  -C 4  alkoxy, phenoxy, C 7  -C 10  phenylalkoxy and C 2  -C 5  acyloxy; X, Y and Z independently represent methyne or nitrogen atom; or a pharmaceutically acceptable salt thereof.

This application is continuation of now abandoned application Ser. No 08/779,623, filed Jan. 7, 1997, which application is a continuation of now abandoned application, Ser. No. 08/266,637, filed Jun. 28, 1994.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to novel phosphonate-nucleotide ester derivatives or pharmaceutically acceptable salts thereof. More particularly, it relates to novel phosphonate-nucleotide ester derivatives or pharmaceutically acceptable salts thereof which can be orally administered as antiviral agents.

2. Background of the Invention

Infectious viral diseases have been recognized as medically important problems. For treatment of such diseases, drugs having antiviral activity but no inhibitory activity on growth of normal cell lines have been developed. For example, 9-(2-phosphonylmethoxy)ethyladenine (PMEA), 9-(2-phosphonylmethoxy)ethyl-2,6-diaminopurine (PMDAP) etc. have been reported to be effective on herpes simplex viruses type-I and II (HSV-1 and HSV-2), human immunodeficiency virus (HIV), hepatitis B virus (Yokota et al., Antimicrob. Agents Chemother., 35, 394 (1991); Votruba et al., Mol. Pharmacol., 32, 524 (1987)].

The problems of these nucleotides and ionic organophosphate esters are their deficiency of oral absorptivity [see, De Clercq et al., Antimicrob. Agents Chemother., 33, 185 (1989)]. Therefore, these compounds should be parenterally administered, for example, by intravenous or intramuscular injection, to attain sufficient blood concentration to elicit their effect.

However, it is difficult to apply treatment utilizing parenteral administration unless the subject is in a hospital. Accordingly, it is not a preferred method to treat subjects suffering from altricious diseases such as AIDS and HBV diseases. Accordingly, there required development of drugs which have antiviral activity and can be parenterally administered. Up to date, no drugs have been put into practical use.

SUMMARY OF THE INVENTION

The present inventors have studied intensively to solve the above problems. As the results, we have found that the object can be attained using a certain kind of phosphonatenucleotide esters, and have attained the present invention.

That is, the point of the present invention resides in phosphonatenucleotide ester derivatives of the following general formula (I): ##STR3## (wherein R¹ and R² independently represent hydrogen, halogen, hydroxyl, mercapto, C₆ -C₁₀ arylthio or amino), R³ represents C₁ -C₄ alkyl or ethyl having one or more substituents selected from the group consisting of fluorine, C₁ -C₄ alkoxy, phenoxy, C₇ -C₁₀ phenylalkoxy and C₂ -C₅ acyloxy; R⁴ represents ethyl having one or more substituents selected from the group consisting of fluorine, C₁ -C₄ alkoxy, phenoxy, C₇ -C₁₀ phenylalkoxy and C₂ -C₅ acyloxy; X, Y and Z independently represent methyne or nitrogen atom); or pharmaceutically acceptable salts thereof.

DETAILED DESCRIPTION OF THE INVENTION

The present invention will be explained in detail.

Phosphonate-nucleotide ester derivatives of the present invention are represented by the above general formula (I). In the above general formula (I), halogen atoms in R¹ and R² include, for example, fluorine, chlorine, bromine, inodine; C₆ -C₁₀ arylthio includes, for example, phenylthio, tolylthio, naphthylthio. C₁ -C₄ alkyl in R³ includes, for example, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, sec-butyl, tert-butyl. C₁ -C₄ alkoxy as a substituent on ethyl in R³ includes, for example, methoxy, ethoxy, n-propoxy, i-propoxy, butoxy. C₇ -C₁₀ phenylalkoxy includes, for example, phenyl-C₁ -C₄ alkoxy such as benzyloxy, phenethyloxy, phenylpropoxy. C₂ -C₅ acyloxy includes, for example, acetoxy, propionyloxy, butyryloxy, i-butyryloxy, valeryloxy. C₁ -C₄ alkoxy, C₇ -C₁₀ phenylalkoxy and C₂ -C₅ acyloxy as substituents on ethyl in R⁴ include those on ethyl in R³.

A preferred ring A in the above general formula (I) includes: ##STR4## (wherein R¹ and R² independently represent hydrogen, halogen, hydroxyl, mercapto, C₆ -C₁₀ arylthio or amino).

A particularly preferred A is ##STR5## (wherein R¹ represents hydrogen, chlorine, hydroxyl, mercapto, tolylthio or amino; R² represents hydrogen, chlorine, iodine, hydroxyl or amino); ##STR6## (wherein R¹ represents amino; R² represents hydrogen); or ##STR7## (wherein R¹ and R² represent amino).

R³ is preferably C₁ -C₃ alkyl, 2,2,2-trifluoroethyl or an ethyl group having a substituent selected from a group consisting of C₁ -C₃ alkoxy, phenoxy, C₇ -C₁₀ phenylalkoxy and C₂ -C₅ acyloxy. Particularly, C₁ -C₃ alkyl or 2,2,2-trifluoroethyl is preferred.

R⁴ is preferably 2,2,2-trifluoroethyl or an ethyl group having a substituent selected from a group consisting of C₁ -C₃ alkoxy, phenoxy, C₇ -C₁₀ phenylalkoxy and C₂ -C₅ acyloxy. Particularly, 2,2,2-trifluoroethyl is preferred. When R³ or R⁴ represents a substituted ethyl group, such an ethyl group is preferably substituted at 2-position. Further, at least one of R³ and R⁴ is preferably 2,2,2-trifluoroethyl. X and Z are preferably nitrogen atoms.

Phosphonate-nucleotide ester derivatives of the present invention represented by the above general formula (I) can form pharmaceutically acceptable salts thereof. Examples of such salt include, for example, in the presence of acidic groups, metal salt such as lithium, sodium, potassium, magnesium, calcium salt, ammonium salt such as methylammonium, dimethylammonium, trimethylammonium, dicyclohexylammonium; in the presence of basic groups, mineral salts such as hydrochloride, hydrobromide, sulfate, nitrate, phosphate, organic salts such as methanesulfonate, benzenesulfonate, paratoluenesulfonate, acetate, propionate, tartrate, fumarate, maleate, malate, oxalate, succinate, citrate, benzoate, mandelate, cinnamate, lactate.

Compounds of the present invention may form tautomers such as keto-enol tautomers depending on the substituents. Such tautomers are also included in the present invention.

Examples of the present compounds are shown in the following tables 1 to 7 (in the tables, P.S. indicates the position of the substituent: ##STR8## as X, Y or Z; and C for X, Y or Z represents --CH═).

                                      TABLE 1                                      __________________________________________________________________________      ##STR9##                                                                      Comp.                                                                          No. R.sup.1                                                                            R.sup.2                                                                            R.sup.3    R.sup.4    X Y Z P.S.                                   __________________________________________________________________________     1   --H --H --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      2   --H --H --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      3   --H --H --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      4   --H --H --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      5   --H --H --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      6   --H --H --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      7   --H --H --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      8   --H --H --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      9   --H --H --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      10  --H --H --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      11  --H --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      12  --H --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      13  --H --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      14  --H --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      15  --H --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      16  --H --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      17  --H --H --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      18  --H --H --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      19  --H --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      20  --H --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      21  --H --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      22  --H --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      23  --H --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      24  --H --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      25  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      26  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      27  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      28  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      29  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      30  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      31  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      32  --H --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      33  --H --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      34  --H --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      35  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      36  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      37  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      38  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      39  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      40  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      41  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      42  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      43  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      44  --H --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      45  --H --H --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      46  --H --H --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      47  --H --H --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      48  --H --H --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      49  --H --H --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      50  --H --H --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      51  --H --OH                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      52  --H --OH                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      53  --H --OH                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      54  --H --OH                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      55  --H --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      56  --H --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      57  --H --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      58  --H --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      59  --H --OH                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      60  --H --OH                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      61  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      62  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      63  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      64  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      65  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      66  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      67  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      68  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      69  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      70  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      71  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      72  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      73  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      74  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      75  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      76  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      77  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      78  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      79  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      80  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      81  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      82  --H --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      83  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      84  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      85  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      86  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      87  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      88  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      89  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      90  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      91  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      92  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      93  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      94  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      95  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      96  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      97  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      98  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      99  --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.6                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      100 --H --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      101 --H --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      102 --H --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      103 --H --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      104 --H --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      105 --H --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      106 --H --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      107 --H --NH.sub.2                                                                         --CF.sub.2 Cf3                                                                            --CH.sub.2 CF.sub.3                                                                       N C N X                                      108 --H --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      109 --H --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      110 --H --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      111 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      112 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      113 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      114 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      115 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      116 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      117 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      118 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      119 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      120 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      121 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      122 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      123 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      124 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      125 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      126 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      127 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      128 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      129 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      130 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      131 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      132 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      133 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      134 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      135 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      136 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      137 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      138 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      139 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      140 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      141 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      142 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      143 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      144 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      145 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      146 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      147 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      148 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      149 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      150 --H --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      151 --OH                                                                               --H --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      152 --OH                                                                               --H --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      153 --OH                                                                               --H --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      154 --OH                                                                               --H --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      155 --OH                                                                               --H --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      156 --OH                                                                               --H --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      157 --OH                                                                               --H --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      158 --OH                                                                               --H --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      159 --OH                                                                               --H --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      160 --OH                                                                               --H --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      161 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      162 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      163 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      164 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      165 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      166 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      167 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      168 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      169 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      170 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      171 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      172 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      173 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      174 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      175 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      176 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      177 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      178 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      179 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      180 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      181 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      182 --OH                                                                               --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      183 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      184 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      185 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      186 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      187 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      188 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      189 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      190 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      191 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      192 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      193 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      194 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      195 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      196 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      197 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      198 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      199 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      200 --OH                                                                               --H --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      201 --OH                                                                               --OH                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      202 --OH                                                                               --OH                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      203 --OH                                                                               --OH                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      204 --OH                                                                               --OH                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      205 --OH                                                                               --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      206 --OH                                                                               --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      207 --OH                                                                               --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      208 --OH                                                                               --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      209 --OH                                                                               --OH                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      210 --OH                                                                               --OH                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      211 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      212 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      213 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      214 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      215 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      216 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      217 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      218 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      219 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      220 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      221 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      222 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      223 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      224 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      225 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      226 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      227 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      228 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      229 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      230 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      231 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      232 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      233 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      234 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      235 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      236 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      237 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      238 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      239 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      240 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      241 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      242 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      243 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      244 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      245 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      246 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      247 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      248 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      249 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      250 --OH                                                                               --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      251 --OH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      252 --OH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      253 --OH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      254 --OH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      255 --OH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      256 --OH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      257 --OH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      258 --OH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      259 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      260 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      261 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      262 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      263 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      264 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      265 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      26& --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      267 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      268 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      269 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      270 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      271 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      272 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      273 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      274 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      275 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      276 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      277 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      278 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      279 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      280 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      281 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      282 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      283 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      284 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      285 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      286 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      287 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      288 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      289 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      290 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      291 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      292 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      293 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      294 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      295 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      296 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      297 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      298 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      299 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.6                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      300 --OH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.6                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.6                                                  N C N Z                                      301 --NH.sub.2                                                                         --H --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      302 --NH.sub.2                                                                         --H --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      303 --NH.sub.2                                                                         --H --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      304 --NH.sub.2                                                                         --H --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N z                                      305 --NH.sub.2                                                                         --H --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      306 --NH.sub.2                                                                         --H --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      307 --NH.sub.2                                                                         --H --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      308 --NH.sub.2                                                                         --H --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      309 --NH.sub.2                                                                         --H --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      310 --NH.sub.2                                                                         --H --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      311 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      312 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      313 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      314 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      315 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      316 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      317 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      318 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      319 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      320 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      321 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      322 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      323 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      324 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      325 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      326 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      327 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      328 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      329 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      330 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      331 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      332 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      333 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      334 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      335 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      336 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      337 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      338 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      339 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      340 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      341 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      342 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      343 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      344 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      345 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      346 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      347 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      348 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      349 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      350 --NH.sub.2                                                                         --H --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      351 --NH.sub.2                                                                         --I --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      352 --NH.sub.2                                                                         --I --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      353 --NH.sub.2                                                                         --I --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      354 --NH.sub.2                                                                         --I --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      355 --NH.sub.2                                                                         --I --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      356 --NH.sub.2                                                                         --I --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      357 --NH.sub.2                                                                         --I --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      358 --NH.sub.2                                                                         --I --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      359 --NH.sub.2                                                                         --I --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      360 --NH.sub.2                                                                         --I --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      361 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      362 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      368 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      364 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      365 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      366 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      367 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      368 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      369 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      370 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      371 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      372 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      373 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      374 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      375 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      376 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      377 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      378 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      379 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      380 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      381 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      382 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      383 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      384 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      385 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      386 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      387 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      388 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      389 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      390 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      391 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      392 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      393 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 CC(O)CH.sub.3                                                         N C N X                                      394 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      395 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      396 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      397 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      398 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      399 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      400 --NH.sub.2                                                                         --I --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      401 --NH.sub.2                                                                         --OH                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      402 --NH.sub.2                                                                         --OH                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      403 --NH.sub.2                                                                         --OH                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      404 --NH.sub.2                                                                         --OH                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      405 --NH.sub.2                                                                         --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      406 --NH.sub.2                                                                         --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      407 --NH.sub.2                                                                         --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      408 --NH.sub.2                                                                         --OH                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      409 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      410 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      411 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      412 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      413 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      414 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      415 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      416 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N z                                      417 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      418 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      419 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      420 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      421 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      422 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      423 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      424 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      425 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      426 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      427 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      428 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      429 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      430 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      431 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      432 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      433 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      434 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      435 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      436 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      437 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      438 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      439 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      440 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      441 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      442 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      443 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      444 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      445 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      446 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      447 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      448 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      449 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      450 --NH.sub.2                                                                         --OH                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      451 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      452 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      453 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      454 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      455 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      456 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      457 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      458 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      459 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      460 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      461 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      462 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      463 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      464 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      465 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      466 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      467 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      468 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      469 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      470 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      471 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      472 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      473 --NH.sub.2                                                                         --NH.sub.2                                                                         --OH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      474 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      475 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      476 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      477 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      478 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      479 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      480 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      481 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      482 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      483 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      484 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      485 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      486 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      487 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      488 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      489 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      490 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      491 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      492 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      493 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      494 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      495 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      496 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      497 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      498 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      499 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      500 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      501 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      502 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      503 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      504 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      505 --Cl                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      506 --Cl                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      507 --Cl                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      508 --Cl                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      509 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      510 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      511 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      512 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      513 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      514 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      515 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      516 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N z                                      517 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      518 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      519 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      520 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      521 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      522 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      523 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      524 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      525 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      526 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      527 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      528 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      529 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      530 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      531 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      532 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      583 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      534 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      535 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      536 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      537 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      538 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      539 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      540 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      541 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      542 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      543 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      544 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      545 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      546 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      547 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      548 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      549 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      550 --Cl                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      551 --Cl                                                                               --Cl                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      552 --Cl                                                                               --Cl                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      553 --Cl                                                                               --Cl                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      554 --Cl                                                                               --Cl                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      555 --Cl                                                                               --Cl                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      556 --Cl                                                                               --Cl                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      557 --Cl                                                                               --Cl                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      558 --Cl                                                                               --Cl                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      559 --Cl                                                                               --Cl                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      560 --Cl                                                                               --Cl                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      561 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      562 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      563 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      564 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      565 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      566 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      567 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      568 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      569 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      570 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      571 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      572 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      573 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      574 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      575 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      576 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      577 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      578 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      579 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      580 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      581 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      582 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      583 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      584 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      585 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      586 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      587 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      588 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      589 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      590 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      591 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      592 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      593 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      594 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      595 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      596 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      597 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      598 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      599 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      600 --Cl                                                                               --Cl                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      601 --SH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      602 --SH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      603 --SH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      604 --SH                                                                               --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      605 --SH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      606 --SH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      607 --SH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      608 --SH                                                                               --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      609 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      610 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      611 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      612 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      613 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      614 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      615 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      616 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      617 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      618 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      619 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      620 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      621 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      622 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      623 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      624 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      625 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      626 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      627 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      628 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      629 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      630 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      631 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      632 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      633 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      634 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      635 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      636 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      637 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      638 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      639 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      640 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      641 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      642 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      643 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      644 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      645 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      646 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      647 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      648 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      649 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      650 --SH                                                                               --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      651 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N N X                                      652 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N N Y                                      653 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N N Z                                      654 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N N X                                      655 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N N Y                                      656 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N N Z                                      657 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N N X                                      658 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N N Y                                      659 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N N Z                                      660 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N X                                      661 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Y                                      662 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Z                                      663 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N X                                      664 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Y                                      665 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Z                                      666 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N N X                                      667 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N N Y                                      668 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N N Z                                      669 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      670 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      671 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      672 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N N X                                      673 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N N Y                                      674 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N N Z                                      675 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N N X                                      676 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N N Y                                      677 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N N Z                                      678 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N N X                                      679 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N N Y                                      680 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N N Z                                      681 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      682 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      683 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      684 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N X                                      685 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Y                                      686 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Z                                      687 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N N X                                      688 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N N Y                                      689 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N N Z                                      690 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      691 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      692 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      693 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N X                                      694 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Y                                      695 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Z                                      696 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CHzCH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   N N N X                                      697 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N Y                                      698 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N Z                                      699 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N N X                                      700 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N N Y                                      701 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N N Z                                      702 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N N X                                      703 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N N Y                                      704 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N N Z                                      705 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      706 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      707 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      708 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N X                                      709 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Y                                      710 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Z                                      711 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N X                                      712 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N Y                                      713 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N                                        714 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N N X                                      715 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N N Y                                      716 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N N Z                                      717 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N N X                                      718 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N N Y                                      719 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N N Z                                      720 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N N X                                      721 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N N Y                                      722 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H7                                                       --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N N Z                                      723 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N N X                                      724 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N N Y                                      725 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N N Z                                      726 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N C X                                      727 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N C Y                                      728 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N C X                                      729 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N C Y                                      730 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N C X                                      731 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N C Y                                      732 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C X                                      733 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C Y                                      734 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C X                                      735 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C Y                                      736 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N C X                                      737 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N C Y                                      738 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C X                                      739 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      740 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N C X                                      741 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N C Y                                      742 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N C X                                      743 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N C Y                                      744 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N C X                                      745 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N C Y                                      746 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C X                                      747 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      748 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C X                                      749 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C Y                                      750 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N C X                                      751 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N C Y                                      752 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C X                                      753 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      754 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C X                                      755 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C Y                                      756 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C X                                      757 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C Y                                      758 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N C X                                      759 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N C Y                                      760 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N C X                                      761 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N C Y                                      762 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C X                                      763 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      764 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C x                                      765 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C Y                                      766 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C X                                      767 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C Y                                      768 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N C X                                      769 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N C Y                                      770 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N C X                                      771 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N C Y                                      772 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N C X                                      773 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N C Y                                      774 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N C X                                      775 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N C Y                                      __________________________________________________________________________

                  TABLE 2                                                          ______________________________________                                          ##STR10##                                                                     Comp.                                                                          No.    R.sup.2          R.sup.4                                                ______________________________________                                         776    --CH.sub.3       --CF.sub.2 CF.sub.3                                    777    --CH.sub.3       --CH.sub.2 CF.sub.3                                    778    --CF.sub.2 CF.sub.3                                                                             --CF.sub.2 CF.sub.3                                    779    --CF.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    780    --CH.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    781    --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CF.sub.3                                    782    --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          783    --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                   784    --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                            --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                   785    --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CF.sub.3                                    786    --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OCH.sub.3                          787    --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   788    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CF.sub.3                                    789    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          790    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   791    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          792    --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5                                                793    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CF.sub.3                                    794    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   795    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          796    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          797    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                      798    --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5               799    --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7               800    --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9               ______________________________________                                    

                  TABLE 3                                                          ______________________________________                                          ##STR11##                                                                     Comp.                                                                          No.    R.sup.2          R.sup.4                                                ______________________________________                                         801    --CH.sub.3       --CF.sub.2 CF.sub.3                                    802    --CH.sub.3       --CH.sub.2 CF.sub.3                                    803    --CF.sub.2 CF.sub.3                                                                             --CF.sub.2 CF.sub.3                                    804    --CF.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    805    --CH.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    806    --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CF.sub.3                                    807    --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          808    --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                   809    --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                            --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                   810    --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CF.sub.3                                    811    --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OCH.sub.3                          812    --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   813    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CF.sub.3                                    814    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          815    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 CH.sub.6 H.sub.5                   816    --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          817    --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5                                                818    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CF.sub.3                                    819    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   820    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          821    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          822    --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                      823    --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5               824    --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7               825    --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9               ______________________________________                                    

                                      TABLE 4                                      __________________________________________________________________________      ##STR12##                                                                     Comp.                                                                          No. R.sup.1                                                                            R.sup.2                                                                            R.sup.3    R.sup.4    X Y Z P.S.                                   __________________________________________________________________________     826 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N N X                                      827 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N N Y                                      828 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N N Z                                      829 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N N X                                      830 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N N Y                                      831 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N N Z                                      832 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N N X                                      833 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N N Y                                      834 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N N Z                                      835 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N X                                      836 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Y                                      837 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Z                                      838 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N X                                      839 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Y                                      840 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N N Z                                      841 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N N X                                      842 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N N Y                                      843 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N N Z                                      844 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      845 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      846 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      847 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N N X                                      848 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N N Y                                      849 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N N Z                                      850 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N N X                                      851 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N N Y                                      852 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N N Z                                      853 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N N X                                      854 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N N Y                                      855 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N N Z                                      856 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      857 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      858 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      859 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N X                                      860 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Y                                      861 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Z                                      862 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N N X                                      863 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N N Y                                      864 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N N Z                                      865 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      866 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      867 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      868 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N X                                      869 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Y                                      870 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Z                                      871 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N X                                      872 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N Y                                      873 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N Z                                      874 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N N X                                      875 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N N Y                                      876 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N N Z                                      817 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N N X                                      878 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N N Y                                      879 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N N Z                                      880 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N X                                      881 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Y                                      882 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N N Z                                      883 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N X                                      884 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Y                                      885 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N N Z                                      886 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N X                                      887 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N Y                                      888 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N N Z                                      889 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N N X                                      890 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N N Y                                      891 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N N Z                                      892 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N N X                                      893 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N N Y                                      894 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N N Z                                      895 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N N X                                      896 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N N Y                                      897 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N N Z                                      898 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N N X                                      899 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N N Y                                      900 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N N Z                                      901 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N C X                                      902 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N N C Y                                      903 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N C X                                      904 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N N C Y                                      905 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N C X                                      906 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N N C Y                                      907 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C X                                      908 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C Y                                      909 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C X                                      910 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N N C Y                                      911 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N C X                                      912 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N N C Y                                      913 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                               N N C X                                      914 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      915 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N C X                                      916 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N N C Y                                      917 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N C X                                      918 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N N C Y                                      919 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N C X                                      920 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N N C Y                                      921 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C X                                      922 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      923 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C X                                      924 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C Y                                      925 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N C X                                      926 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N N C Y                                      927 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C X                                      928 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      929 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C X                                      930 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C Y                                      931 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C X                                      932 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C Y                                      933 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N C X                                      934 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N N C Y                                      935 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N C X                                      936 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N N C Y                                      937 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C X                                      938 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N N C Y                                      939 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C X                                      940 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N N C Y                                      941 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C X                                      942 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N N C Y                                      943 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N C X                                      944 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N N C Y                                      945 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N C X                                      946 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N N C Y                                      947 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N C X                                      948 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N N C Y                                      949 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N C X                                      950 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N N C Y                                      951 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                      952 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                      953 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                      954 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                      955 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                      956 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                      957 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      958 --NH.sub.2                                                                         --NH.sub.2                                                                         --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      959 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                      960 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                      961 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      962 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      963 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      964 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      965 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                      966 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                      967 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                      968 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                      969 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                      970 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                      971 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      972 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      973 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      974 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      975 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                      976 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                      977 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      978 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      979 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      980 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      981 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      982 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      983 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N X                                      984 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5    N C N Z                                      985 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                      986 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                      987 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                      988 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                      989 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                      990 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                      991 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                      992 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                      993 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                      994 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                      995 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                      996 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                      997 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                      998 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                      999 --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                      1000                                                                               --NH.sub.2                                                                         --NH.sub.2                                                                         --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                      __________________________________________________________________________

                  TABLE 5                                                          ______________________________________                                          ##STR13##                                                                     Comp.                                                                          No.    R.sup.3          R.sup.4                                                ______________________________________                                         1001   --CH.sub.3       --CF.sub.2 CF.sub.3                                    1002   --CH.sub.3       --CH.sub.2 CF.sub.3                                    1003   --CF.sub.2 CF.sub.3                                                                             --CF.sub.2 CF.sub.3                                    1004   --CF.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    1005   --CH.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    1006   --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CF.sub.3                                    1007   --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          1008   --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                   1009   --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                            --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                   1010   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CF.sub.3                                    1011   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OCH.sub.3                          1012   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1013   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CF.sub.3                                    1014   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          1015   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1016   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1017   --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5                                                1018   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CF.sub.3                                    1019   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1020   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1021   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1022   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                      1023   --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5               1024   --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7               1025   --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9               ______________________________________                                    

                  TABLE 6                                                          ______________________________________                                          ##STR14##                                                                     Comp.                                                                          No.    R.sup.3          R.sup.4                                                ______________________________________                                         1026   --CH.sub.3       --CF.sub.2 CF.sub.3                                    1027   --CH.sub.3       --CH.sub.2 CF.sub.3                                    1028   --CF.sub.2 CF.sub.3                                                                             --CF.sub.2 CF.sub.3                                    1029   --CF.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    1030   --CH.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    1031   --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CF.sub.3                                    1032   --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          1033   --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                   1034   --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                            --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                   1035   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CF.sub.3                                    1036   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OCH.sub.3                          1037   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1038   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CF.sub.3                                    1039   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          1040   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1041   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1042   --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5                                                1043   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CF.sub.3                                    1044   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1045   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1046   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1047   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                      1048   --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5               1049   --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7               1050   --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9               ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                          ##STR15##                                                                     Comp.                                                                          No.    R.sup.3          R.sup.4                                                ______________________________________                                         1051   --CH.sub.3       --CF.sub.2 CF.sub.3                                    1052   --CH.sub.3       --CH.sub.2 CF.sub.3                                    1053   --CF.sub.2 CF.sub.3                                                                             --CF.sub.2 CF.sub.3                                    1054   --CF.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    1055   --CH.sub.2 CF.sub.3                                                                             --CH.sub.2 CF.sub.3                                    1056   --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CF.sub.3                                    1057   --CH.sub.2 CH.sub.2 OCH.sub.3                                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          1058   --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                   1059   --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                            --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                   1060   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CF.sub.3                                    1061   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OCH.sub.3                          1062   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1063   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CF.sub.3                                    1064   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.3                          1065   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1066   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                                   --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1067   --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                            --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                   H.sub.5                                                1068   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CF.sub.3                                    1069   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                   1070   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1071   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5          1072   --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                      1073   --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5               1074   --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7               1075   --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                        --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9               ______________________________________                                    

                                      TABLE 1                                      __________________________________________________________________________      ##STR16##                                                                     Comp.                                                                          No. R.sup.1                                                                           R.sup.2                                                                           R.sup.3    R.sup.4    X Y Z P.S.                                     __________________________________________________________________________     1076                                                                               --Cl                                                                              --H                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N X                                        1077                                                                               --Cl                                                                              --H                                                                               --CH.sub.3 --CF.sub.2 CF.sub.3                                                                       N C N Z                                        1078                                                                               --Cl                                                                              --H                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N X                                        1079                                                                               --Cl                                                                              --H                                                                               --CH.sub.3 --CH.sub.2 CF.sub.3                                                                       N C N Z                                        1080                                                                               --Cl                                                                              --H                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N X                                        1081                                                                               --C1                                                                              --H                                                                               --CF.sub.2 CF.sub.3                                                                       --CF.sub.2 CF.sub.3                                                                       N C N Z                                        1082                                                                               --Cl                                                                              --H                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                        1083                                                                               --Cl                                                                              --H                                                                               --CF.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                        1084                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N X                                        1085                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CF.sub.3                                                                       --CH.sub.2 CF.sub.3                                                                       N C N Z                                        1086                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                        1087                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                        1088                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                        1089                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.3                                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                        1090                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N X                                        1091                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      N C N Z                                        1092                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N X                                        1093                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      --CH.sub.2 CH.sub.2 OC.sub.3 H.sub.7                                                      N C N Z                                        1094                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N X                                        1095                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CF.sub.3                                                                       N C N Z                                        1096                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                        1097                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                        1098                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                        1099                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                        1100                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N X                                        1101                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CF.sub.3                                                                       N C N Z                                        1102                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                        1103                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                        1104                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                        1105                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                        1106                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                        1107                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                        1108                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                              N.sub.5                                                                          C N X                                        1109                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6 H.sub.5                                      --CH.sub.2 CH.sub.2 OC.sub.2 H.sub.4 C.sub.6                                              N.sub.5                                                                          C N Z                                        1110                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N X                                        1111                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CF.sub.3                                                                       N C N Z                                        1112                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N X                                        1113                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.3                                                             N C N Z                                        1114                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N X                                        1115                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      N C N Z                                        1116                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N X                                        1117                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                                             N C N Z                                        1118                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N X                                        1119                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         --CH.sub.2 CH.sub.2 OC(O)CH.sub.3                                                         N C N Z                                        1120                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N X                                        1121                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.2 H.sub.5                                                  N C N Z                                        1122                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N X                                        1123                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.3 H.sub.7                                                  N C N Z                                        1124                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N X                                        1125                                                                               --Cl                                                                              --H                                                                               --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  --CH.sub.2 CH.sub.2 OC(O)C.sub.4 H.sub.9                                                  N C N Z                                        __________________________________________________________________________

The compound of the present invention may be synthesized according to the following reaction scheme (1) or (2):

Reaction Scheme (I): ##STR17## (wherein, R¹ to R⁴, and a ring A are as defined above; R⁵ is an ethyl group having one or more substituents selected from a group consisting of fluorine, C₁ -C₄ alkoxy, phenoxy, C₇ -C₁₀ phenylalkoxy, C₂ -C₅ acyloxy, C₁ -C₄ acylamino and hydroxyl; W is a leaving group such as halogen, paratoluenesulfonyloxy, methanesulfonyloxy, trifluoromethanesulfonyloxy).

A compound of Formula (II) is reacted with a compound of Formula (III) at 10-250° C., preferably at 130-180° C. for 0.1-20 hours, preferably for 3-15 hours.

A compound of Formula (IV) may be separated and purified, as needed, by the conventional means for separation and purification, for example, by distillation, adsorption, partition chromatography. A compound of Formula (IV) may be separated and purified as described above, but may be directly used in the subsequent reaction without purification.

Subsequently, a compound of Formula (IV) is reacted with a compound of Formula (V) in the presence of a base, for example, sodium carbonate, potassium carbonate, cesium carbonate, sodium hydride, potassium hydride, triethylamine, diazabicycloundecene in a solvent such as acetonitrile, tetrahydrofuran, dimethylsulfoxide, dimethylformamide, methylpyrrolidone at 10-200° C., preferably at 50-150° C., for 0.1 to 100 hours, preferably for 5-20 hours to give a compound (I).

Reaction Scheme (2): ##STR18## (wherein, R¹ to R⁴, and a ring A are as defined above; Me is methyl and Et is ethyl)

A compound of Formula (VI) is reacted with trimethylsilyldiethylamine in a solvent, for example, in a chlorinated solvent such as dichloromethane, dichloroethane, chloroform at the temperature around room temperature for about an hour. In this case, two moles or more trimethylsilyldiethylamine is used based on one mole of a compound of Formula (VI).

Subsequently, after the reaction mixture is concentrated to dryness, the residue is dissolved in a chlorinated solvent such as dichloromethane, and two mole or more oxalyl chloride is added to 1 mole of the compound of Formula (VI), and the reaction is carried out in the presence of a catalytic amount of dimethylformamide under ice cooling for about an hour, then at the temperature around room temperature for about an hour.

After a solvent is distilled off, thus obtained compound of Formula (VII) without purification is usually reacted with R³ OH, R⁴ OH in a solvent, for example, a chlorinated solvent such as dichloromethane or pyridine, acetonitrile, tetrahydrofuran, dimethylsulfoxide, dimethylformamide, methylpyrrolidone, etc. at 10-100° C., preferably at 20-30° C. for 0.1-100 hours, preferably for 5-24 hours to give a compound (I).

A compound of Formula (I) which may be obtained according to the above reaction scheme (1) or (2) may be separated and purified by properly selecting conventional means for separation and purification for nucleotide, for example, recrystallization, adsorption, ion-exchange, partition chromatography or the like, as needed. Various base derivatives may be derived from thus obtained compound of Formula (I) according to the known methods, as needed.

As the compound of Formula (II), (III) or (VI) in the above reaction schemes, those commercially available reagents may be purchased and used. Alternatively, those synthesized according to the known methods may be suitably used.

As shown in the following experimental examples, the compound of the present invention may be expected as antiviral agents which can be orally administered, and further expected to possess antineoplastic activity like other ionic phosphonate-nucleotide analogs. The viruses of interest may not be particularly limited, but include, for example, RNA viruses such as human immunodeficiency virus, influenza virus, hepatitis C virus; DNA viruses such as herpes simplex virus type-I, herpes simplex virus type-II, cytomegalovirus, herpes zoster, hepatitis B virus. More preferably, it is hepatitis B virus.

The compound of the present invention can be orally administered to a human patient. The dose is appropriately determined depending on, for example, the age, the conditions, the weight of the subject. Generally, 1-1,000 mg/kg, preferably 5-50 mg/kg is administered once or more daily.

The compound of the present invention is preferably used as a composition comprising pharmaceutically acceptable carrier such as conventional pharmaceutical carrier, excipient, etc. Such carrier may be either solid or liquid. Solid carrier includes, for example, lactose, kaolin, sucrose, crystalline cellulose, corn starch, talc, agar, pectin, stearic acid, magnesium stearate, lecithin, sodium chloride; and liquid carrier includes, for example, glycerin, peanut oil, polyvinyl pyrrolidone, olive oil, ethanol, benzyl alcohol, propylene glycol, physiological saline, water, etc.

Various dosage form may be employed, including tablets, powders, granules, troches, etc. when a solid carrier is used; and syrups, soft gelatin capsules, gels, pastes, etc. when a liquid carrier is used.

EXAMPLE

The present invention will be explained in detail in the following examples, which are not a limitation of the scope of the invention.

Example 1

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]adenine (compound No. 309 in Table 1)

2-Chloroethylchloromethylether (1.96 g, 15.2 mmol) was reacted with tris(2,2,2-trifluoroethyl)phosphite (5 g, 15.2 mmol) at 160° C. for 14 hours to quantitatively obtain 5.15 g of 2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl chloride.

Adenine (2.07 g, 15.3 mmol) was suspended in dimethylformamide (30 ml) and reacted with sodium hydride (60% in mineral oil, 0.61 g) at 100° C. for an hour. Subsequently, 2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl chloride (5.15 g) was added to the above reaction solution and reacted at 100° C. for 5 hours. After reaction was over, the product was cooled to room temperature and concentrated to dryness. The residue was dissolved in chloroform, adsorbed on silica gel column and eluted with 5% methanol/chloroform to give the title compound (2.77 g, 42%).

m.p.: 111-113° C. (ethyl acetate/hexane)

1H-NMR (CDCl3, δ): 3.91 (d, J=8.0 Hz, 2H) 3.94 (t, J=5.0 Hz, 2 H) 4.30-4.39 (m, 6H) 6.00 (br, 2H) 7.83 (s, 1H) 8.31 (s. 1H)

Example 2

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-2,6-diaminopurine (compound No. 459 in Table 1)

The procedure in Example 1 was repeated, except that 2,6-diaminopurine was used instead of adenine, to obtain the title compound.

m.p.: 108° C. (ether)

1H-NMR (CDCl3, δ): 3.91-3.95 (m, 4H) 4.24 (t, J=5.1 Hz, 2H) 4.30-4.42 (m, 4H) 4.68 (br, 2H) 5.32 (br, 2H) 7.57 (s, 1H)

Example 3

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-2-amino-6-chloropurine (compound No. 509 in Table 1)

The procedure in Example 1 was repeated, except that 2-amino-6-chloropurine was used instead of adenine, to obtain the title compound.

m.p.: 132° C. (ether)

1H-NMR (CDCl3, δ) :3.91 (t, J=4.7 Hz, 2H) 3.94 (d, J=7.6 Hz, 2H) 4.30 (t, J=4.7 Hz, 2H) 4.35-4.49 (m, 4H) 5.16 (br, 2H) 7.83 (s, 1H)

Example 4

Production of 7-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-2-amino-6-chloropurine (compound No. 510 in Table 1)

The procedure in Example 1 was repeated, except that 2-amino-6-chloropurine was used instead of adenine, to obtain the title compound.

m.p.: amorphous

1H-NMR (CDCl3, δ): 3.93 (t, J=5.1 Hz, 2H) 3.94 (d, J=7.7 Hz, 2H) 4.24 (t, J=5.1 Hz, 2H) 4.31-4.42 (m, 4H) 4.66 (br, 2H) 5.27 (br, 2H) 7.56 (s, 1H)

Example 5

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-8-aza-2,6-diaminopurine (compound No. 663 in Table 1)

The procedure in Example 1 was repeated, except that 8-aza-2,6-diaminopurine was used instead of adenine, to obtain the title compound.

m.p.: 169° C. (ethanol)

¹ H-NMR (Me₂ SO-d₆, δ) : 3.98 (t, J=5.1 Hz, 2H) 4.11 (d, J=7.8 Hz, 2H) 4.46-4.86 (m, 6H) 6.38 (br, 2H) 7.18-8.00 (m, 2H)

Example 6

Production of 8-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-8-aza-2,6-diaminopurine (compound No. 664 in Table 1)

The procedure in Example 1 was repeated, except that 8-aza-2,6-diaminopurine was used instead of adenine, to obtain the title compound.

m.p.: 128° C. (diisopropyl ether)

1H-NMR (Me2SO-d6, δ): 4.03-4.15 (m, 4H) 4.55-4.71 (m, 4H) 6.05 (br, 2H) 7.50 (br, 2H)

Example 7

Production of 7-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]theophylline (compound No. 805 in Table 3)

The procedure in Example 1 was repeated, except that theophylline was used instead of adenine, to obtain the title compound.

m.p.: 77° C. (hexane)

1H-NMR (CDCl3, δ): 3.41 (s, 3H) 3.60 (s, 3H) 3.93 (d, J=8.1 Hz, 2H) 3.94 (t, J=5.0 Hz, 2H) 4.31-4.48 (m, 4H) 4.52 (t, J=5.0 Hz, 2H) 7.60 (s, 1H)

Example 8

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-2,6-dichloropurine (compound No. 559 in Table 1)

The procedure in Example 1 was repeated, except that 2,6-dichloropurine was used instead of adenine, to obtain the title compound.

m.p.: 71-72° C. (ethyl acetate/hexane)

1H-NMR (CDCl3, δ) : 3.90-4.08 (m, 4H) 4.32-4.52 (m, 6H) 8.19 (s, 1H)

Example 9

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-3-deaza-8-aza-2,6-diaminopurine (compound No. 838 in Table 4)

The procedure in Example 1 was repeated, except that 3-deaza-8-aza-2,6-diaminopurine was used instead of adenine, to obtain the title compound.

m.p.: 116-122° C. (ether)

¹ H-NMR (Me₂ SO-d₆, δ): 3.94 (t, J=5.2 Hz, 2H) 4.09 (d, J=7.7 Hz, 2H) 4.46-4.78 (m, 6H) 5.55 (s, 2H) 5.57 (s, 1H) 6.66 (s, 2H)

Example 10

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-7-deaza-8-aza-2,6-diaminopurine (compound No. 734 in Table 1)

The procedure in Example 1 was repeated, except that 7-deaza-8-aza-2,6-diaminopurine was used instead of adenine, to obtain the title compound.

m.p.: 54-64° C. (ether)

¹ H-NMR (Me₂ SO-d₆, δ): 3.91 (t, J=5.3 Hz, 2H) 4.07 (d, J=8.0 Hz, 2H) 4.27 (t, J=5.3 Hz, 2H) 4.52-4.78 (m, 4H) 8.00 (s, 1H)

Example 11

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-6-chloropurine (compound No. 1,084 in Table 1)

The procedure in Example 1 was repeated, except that 6-chloropurine was used instead of adenine, to obtain the title compound.

m.p.: oil

¹ H-NMR (CDCl₃, δ) 3.95 (d, J=7.8 Hz, 2H) 4.00 (t, J=4.9 Hz, 2H) 4.34-4.48 (m, 4H) 4.52 (t, J=4.9 Hz, 2H) 8.20 (s, 1H) 8.75 (s, 1H)

Example 12

Production of 9-[2-[methyl(2,2,2-trifluoloethyl)phosphonylmethoxy]ethyl]adenine (compound No. 303 in Table 1)

The compound obtained in Example 1 (1 g, 2.3 mmol) was dissolved in methanol (10 ml), to which was added silica gel (5 g). After reaction at 50° C. for 7 hours, the product was concentrated to dryness. The residue was eluted with 5% methanol/chloroform to obtain the title compound (0.75 g, 88%).

m.p.: 107-110° C. (ethyl acetate/hexane)

1H-NMR (CDCl3, δ): 3.74 (d, J=11.1 Hz, 3H) 3.83 (d, J=8.3 Hz, 2H) 3.93 (t, J=4.1 Hz, 2H) 4.30-4.39 (m, 4H) 5.65 (br, 2H) 7.86 (s, 1H) 8.33 (s. 1H)

Example 13

Production of 9-[2-[methyl(2,2,2-trifluoloethyl)phosphonylmethoxy]ethyl]-2,6-diaminopurine (compound No. 453 in Table 1)

The procedure in Example 9 was repeated, except that the compound obtained from Example 2 was used instead of that obtained from Example 1, to obtain the title compound.

m.p.: amorphous

1H-NMR (CDCl3, δ) : 3.77 (d, J=11.0 Hz, 3H) 3.86 (d, J=8.2 Hz, 2H) 3.91 (t, J=5.0 Hz, 2H) 4.24 (t, J=4.1 Hz, 2H) 4.25-4.42 (m, 2H) 4.69 (br, 2H) 5.35 (br, 2H) 7.6 0(s. 1H)

Example 14

Production of 9-[[2-[bis(2-methoxyethyl)phosphonylmethoxy]ethyl]adenine (compound No. 313 in Table 1)

9-[(2-Phosphonylmethoxy)ethyl]adenine (1 g, 3.5 mmol) was suspended in dichloromethane (10 ml) and reacted with trimethylsilyldiethylamine (3 ml) at room temperature for an hour and concentrated to dryness. The residue was dissolved in dichloromethane (10 ml), to which were added dimethylformamide (0.05 ml) and oxalyl chloride (0.9 ml). The mixture was reacted under ice-cooling for an hour, then at room temperature for an hour. After solvent was distilled off, the residue was dissolved in pyridine (20 ml) and reacted with 2-methoxyethanol (0.76 g) at room temperature for 12 hours. After concentration to dryness, the residue was dissolve in chloroform, adsorbed on silica gel column, eluted with 5% methanol/chloroform to give the title compound (0.3 g, 22%).

m.p.: 90-93° C. (ethyl acetate/hexane)

1H-NMR (CDCl3, δ) : 3.35 (s, 6H) 3.55 (d, J=4.6 Hz, 4H) 3.86 (d, J=8.2 Hz, 2H) 3.95 (t, J=4.9 Hz, 2H) 4.16-4.19 (m, 4H) 4.40 (t, J=4.9 Hz, 2H) 5.67 (br, 2H) 7.98 (s, 1H) 8.35 (s. 1H)

Example 15

Production of 9-[[2-bis(2-phenoxyethyl)phosphonylmethoxy]ethyl]adenine (compound No. 323 in Table 1)

The procedure in Example 11 was repeated, except that 2-phenoxyethanol was used instead of 2-methoxyethanol, to obtain the title compound.

m.p.: 112-115° C. (hexane)

1H-NMR (CDCl3, δ): 3.88 (t, J=4.8 Hz, 2H) 3.95 (d, J=8.0 Hz, 2H) 4.07 (t, J=4.4 Hz, 4H) 4.21-4.26 (m, 4H) 4.30 (t, J=4.8 Hz, 2H) 5.55 (br, 2H) 6.85-6.92 (m, 6H) 7.26 (t, J=7.4 Hz, 4H) 8.06 (s, 1H) 8.12 (s. 1H)

Example 16

Production of 9-[[2-bis(2-benzyloxyethyl)phosphonylmethoxy]ethyl]adenine (compound No. 331 in Table 1)

The procedure in Example 11 was repeated, except that 2-benzyloxyethanol was used instead of 2-methoxyethanol to obtain the title compound.

m.p.: 45-48° C. (hexane)

1H-NMR (CDCl3, δ) : 3.61 (d, J=4.6 Hz, 4H) 3.81 (d, J=8.1 Hz, 2H) 3.84 (t, J=5.0 Hz, 2H) 4.17-4.23 (m, 4H) 4.30 (t, J=5.0 Hz, 2H) 4.51 (s, 4H) 5.49 (br, 2H) 7.29-7.33 (m, 10H) 7.91 (s, 1H) 8.35 (s, 1H)

Example 17

Production of 9-[[2-bis(2-acetoxyethyl)phosphonylmethoxy]ethyl]adenine (compound No. 343 in Table 1)

The procedure in Example 11 was repeated, except that 2-acetoxyethanol was used instead of 2-methoxyethanol, to obtain the title compound.

m.p.: 68-70° C. (ethyl acetate/hexane)

1H-NMR (CDCl3, δ): 2.08 (s, 6H) 3.84 (d, J=8.3 Hz, 2H) 3.95 (t, J=4.9 Hz, 2H) 4.22-4.26 (m, 8H) 4.42 (t, J=4.9 Hz, 2H) 5.63 (br, 2H) 7.94 (s, 1H) 8.36 (s. 1H)

Example 18

Production of 9-[[2-bis(2-valeryloxyethyl)phosphonylmethoxy]ethyl]adenine (compound No. 349 in Table 1)

The procedure in Example 11 was repeated, except that 2-valeryloxyethanol was used instead of 2-methoxyethanol to obtain the title compound.

m.p.: oil

1H-NMR (CDCl3, δ): 0.91 (t, J=7.5 Hz, 6H) 1.36 (qt, J=7.5 Hz, 4H) 1.60 (tt, J=7.5 Hz, 4H) 2.33 (t, J=7.5 Hz, 4H) 3.83 (d, J=8.1 Hz, 2H) 3.95 (t, J=5.0 Hz, 2H) 4.21-4.25 (m, 8H) 4.41 (t, J=5.0 Hz, 2H) 5.73 (br, 2H) 7.94 (s, 1H) 8.35 (s. 1H)

Example 19

Production of 9-[2-bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-2-iodoadenine (compound No. 359 in Table 1)

The procedure in Example 11 was repeated, except that 2,2,2-trifluoroethanol and 9-[(2-phosphonylmethoxy)ethyl]-2-iodoadenine were used instead of 2-methoxyethanol and 9-[(2-phosphonylmethoxy)ethyl]adenine, respectively, to obtain the title compound.

m.p.: 179° C. (CHCl₃)

1H-NMR (Me2SO-d6, δ): 3.88 (t, J=5.0 Hz, 2H) 4.13 (d, J=8.0 Hz, 2H) 4.28 (t, J=5.0 Hz, 2H) 4.56-4.70 (m, 4H) 7.63 (br, 2H) 7.99 (s, 1H)

Example 20

Production of 9-[2-bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]guanine (compound No. 259 in Table 1)

The procedure in Example 1 was repeated, except that 6-O-benzylguanine, which can be synthesized by the known method, was used instead of adenine, to obtain 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-6-O-benzylguanine.

The compound (2.21 g, 4.07 mmol) was dissolved in ethanol (20 ml), to which were added cyclohexene (20 ml) and 20% palladium hydroxide carbon (1.5 g), and the mixture was reacted under reflux for 2 hours. After palladium hydroxide carbon was removed by filtration, the solution was concentrated to dryness. The residue was dissolved in chloroform, adsorbed on a silica gel column and eluted with 5% methanol/chloroform to obtain the title compound (1.01 g, 55%).

m.p.: 214° C. (ethanol)

1H-NMR (Me2SO-d6, δ): 3.86 (t, J=5.1 Hz, 2H) 4.13 (d, J=8.1 Hz, 2H) 4.17 (t, J=5.0 Hz, 2H) 4.58-4.70 (m, 4H) 6.61 (br, 2H) 8.06 (s, 1H) 10.88 (br, 1H)

Example 21

Production of 7-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]guanine (compound No. 260 in Table 1)

Guanosine (1 g, 3.53 mmol) was suspended in dimethylacetaminde (10 ml), to which was added 2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl iodide (1.7 g), and the reaction was carried out at 100° C. for 2 hours. The reaction solution was concentrated to dryness, and the residue was dissolved in 30% methanol/water, adsorbed on an octadecyl silica gel column, eluted with 30% methanol/water to give the title compound (0.1 g, 6.3%).

m.p.: 255° C.(H₂ O)

1H-NMR (Me2SO-d6, δ) 3.89 (t, J=5.0 Hz, 2H) 4.10 (d, J=8.0 Hz, 2H) 4.40 (t, J=5.0 Hz, 2H) 4.57-4.70 (m, 4H) 6.34 (br, 2H) 8.09 (s, 1H) 10.95 (br, 1H)

Example 22

Production of 9-[2-bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]adenine-1-N-oxide (compound No. 780 in Table 2)

The compound in Example 1 (8.12 g, 18.6 mmol) was dissolved in chloroform (150 ml), to which was added m-chloroperbenzoic acid (15 g), and reacted at 50° C. for 2 hours. The separated precipitate was removed by filtration, then adsorbed on a silica gel column and eluted with 5% methanol/chloroform to give the title compound (3.42 g, 42%).

m.p.: 186° C. (ethyl acetate)

1H-NMR (Me2SO-d6, δ) 3.88 (t, J=5.0 Hz, 2H) 4.10 (d, J=8.0 Hz, 2H) 4.36 (t, J=5.0 Hz, 2H) 4.52-4.66 (m, 4H) 8.18 (s, 1H) 8.56 (s, 1H)

Example 23

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-6-thioguanine (compound No. 609 in Table 1)

The compound in Example 3 (800 mg, 1.7 mmol) was dissolved in ethanol (15 ml), to which was added thiourea (157 mg) and reacted under reflux for 4 hours. After reaction was over, the mixture was cooled to room temperature and concentrated to dryness. The residue was dissolved in chloroform, adsorbed on a silica gel column and eluted with 5% methanol/chloroform to give the title compound (252 mg, 32%).

m.p.: 144° C. (ethanol)

1H-NMR (Me2SO-d6, δ): 3.80 (t, J=5.1 Hz, 2H) 4.06-4.16 (m, 4H) 4.49-4.68 (m, 4H) 6.73 (br, 2H) 7.76 (s, 1H)

Example 24

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-2-amino-6-p-toluylthiopurine (compound No. 1,030 in Table 6)

The compound in Example 3 (9.4 mg, 20 mmol) was dissolved in DMF (90 ml). p-Thiocresol (5.23 g) and triethylamine (2.8 ml) were added at room temperature, and the mixture was reacted at 100° C. for 4 hours. After reaction was over, the reaction mixture was cooled to room temperature and concentrated to dryness. The residue was dissolved in chloroform, adsorbed on a silica gel column and eluted with chloroform to give the title compound (9.8 g, 88%).

m.p.: oil

1H-NMR (CDCl3, δ): 2.40 (s, 3H) 3.89-3.96 (m, 4H) 4.26 (d, J=5.1 Hz, 2H) 4.39-4.47 (m, 4H) 4.79 (br, 2H) 7.23 (d, J=9.8 Hz, 2H) 7.31 (d, J=9.8 Hz, 2H) 7.71 (s, 1H)

Example 25

Production of 9-[2-[bis(2,2,2-trifluoroethyl) phosphonylmethoxy]ethyl]-2-hydroxy-6-p-toluylthiopurine (compound No. 1,055 in Table 7)

The compound in Example 21 (6.9 mg, 12.3 mmol) was dissolved in 50% aqueous acetic acid (120 ml). Sodium nitrite (12 g) was added thereto, and the mixture was reacted at 50° C. for 1 hour. After reaction was over, the reaction mixture was cooled to room temperature and concentrated to dryness. The residue was partitioned between chloroform and aqueous sodium bicarbonate, and the chloroform layer was dried on magnesium sulfate and filtered. The filtrate was concentrated to dryness, crystallized from ether to give the title compound (2.31 g, 34%).

m.p.: 176° C. (ether)

1H-NMR (Me2SO-d6, δ) :2.33 (s, 3H) 3.85 (t, J=5.1 Hz, 2H) 4.01 (d, J=8.0 Hz, 2H) 4.25 (d, J=5.1 Hz, 2H) 4.53-4.69 (m, 4H) 7.24 (d, J=8.1 Hz, 2H) 7.43 (d, J=8.1 Hz, 2H) 8.05 (s, 1H) 11.58 (br, 1H)

Example 26

Production of 9-[2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl]-1-methylguanine (compound No. 1,005 in Table 5)

The compound in Example 20 (500 mg, 1.1 mmol) was dissolved in DMF (7 ml), and reacted with potassium carbonate (150 mg), molecular sieves (0.4 nm, 100 mg) and methyl iodide (203 mg) at room temperature for 2 hours. The reaction solution was filtered and concentrated to dryness. The residue was dissolved in chloroform, adsorbed on a silica gel column and eluted with 5% methanol/chloroform to give the title compound (30 mg, 5.8%).

m.p.: oil

¹ H-NMR (Me₂ SO-d₆, δ): 3.27 (s, 3H) 3.80 (d, J=5.0 Hz, 2H) 4.05-4.11 (m, 4H) 4.52-4.68 (m, 4H) 6.98 (br, 2H) 7.59 (s, 1H)

Reference Example 1

Production of 9-[[2-bis(2-acetamidethyl)phosphonylmethoxy]ethyl]adenine ##STR19##

The procedure in Example 11 was repeated, except that 2-acetamide ethanol was used instead of 2-methoxyethanol, to obtain the title compound.

m.p.: oil

1H-NMR (CDCl3, δ): 2.02 (s, 6H) 3.41-3.53 (m, 4H) 3.81 (d, J=8.5 Hz, 2H) 3.94 (t, J=4.9 Hz, 2H) 3.97-4.21 (m, 4H) 4.43 (t, J=4.9 Hz, 2H) 6.18 (br, 2H) 6.77 (br, 2H) 8.00 (s, 1H) 8.34 (s. 1H)

Reference Example 2

Production of 9-[[2-bis(2-hydroxyethyl)phosphonylmethoxy]ethyl]adenine ##STR20##

The compound obtained from Example 13 (1 g, 1.9 mmol) was dissolved in ethanol, 10% palladium-carbon (0.1 g) was added and reacted at 60° C. for 7 hours under hydrogen atmosphere. After palladium-carbon was removed by filtration, the solution was concentrated to dryness. The residue was dissolved in chloroform, adsorbed on a silica gel column, eluted with 5% methanol/chloroform to give the title compound (0.38 g, 55%).

m.p.: 102-104° C. (ethyl acetate)

1H-NMR (Me2SO-d6, δ) 3.50 (q, J=3.9 Hz, 4H) 3.86-3.96 (m, 8H) 4.32 (t, J=5.1 Hz, 2H) 4.85 (t, J=5.6 Hz, 2H) 7.21 (br, 2H) 8.09 (s, 1H) 8.13 (s. 1H)

Experiment 1

Inhibition of HBV growth

HB611 cells (recombinant human lever cancer cell producing HBV, 2×10⁴) was incubated on Dulbecco ME medium containing bovine fetal serum, streptomycin (100 mg/ml), penicillin (100 IU/ml) and G-418 (0.2 mg/ml) at 37° C. On the 2nd and 5th days of cultivation, the medium was changed, then the media containing specimens at final concentration of 10 mM were substituted on the 8th, 11th and 14th days. On 17 days of cultivation, DNA of the cell was recovered. The amount of HBV-DNA was measured by southern blotting, and inhibition of HBV-DNA synthesis in the cell was determined. In addition, the concentration of the compound required for 50% death of the HB611 cells was determined. The results are shown in the following Table 8.

                  TABLE 8                                                          ______________________________________                                                     Inhibition of   LD.sub.50 of HB611 cell                            Compound    HBV-DNA Synthesis (%)                                                                          (μM)                                            ______________________________________                                         Example 1   91.5            >1000                                              Example 2   99.9            840                                                Example 3   99.9            399                                                Example 5   97.2            --                                                 Example 12  86.3            >1000                                              Example 13  100             >1000                                              Example 14  55.0            >1000                                              Example 15  59.7            174                                                Example 16  57.8            178                                                Example 17  66.2            >1000                                              Example 18  73.4            47                                                 Example 20  99.9            --                                                 Example 21  71.3            --                                                 Example 22  76.2            --                                                 Example 23  86.1            --                                                 Example 24  99.9            --                                                 Example 25  99.9            --                                                 Example 26  99.9            --                                                 Reference Example 1                                                                        --              >1000                                              Reference Example 2                                                                        31.0            >1000                                              ______________________________________                                    

Experiment 2

Inhibition of HBV growth in rat or mouse serum upon oral administration

Groups of rats (3 rats per group) were received single oral dose of specimen (1 g/kg or 0.5 g/kg), bled at 1 hour after administration and serum was prepared. Separately, groups of mice (3 mice per group) were received single oral dose of specimen (0.3 g/kg), bled at 30 minutes after administration and serum was prepared.

HB611 cells (2×10⁴) were incubated on Dulbecco ME medium containing 10% bovine fetal serum, streptomycin (100 mg/ml), penicillin (100 IU/ml) and G-418 (0.2 mg/ml) at 37° C. On the 2nd and 5th days of cultivation, the medium was changed, then substituted with a medium containing 5% of the above serum (rat or mouse serum after oral administration of the specimen) on the 8th, 11th and 14th day, and DNA of the cell was recovered on the 17th days of cultivation. The amount of HBV-DNA was measured by southern blotting, and intracellular HBV-DNA synthesis inhibition was determined. For reference, the same experiment was conducted on PMEA. The results are shown in the following Table 9.

                  TABLE 9                                                          ______________________________________                                                              Oral Dosage                                                                              HBV-DNA Synthesis                               Compound     Subject (g/kg)    Inhibition (%)                                  ______________________________________                                         Example 1    Rat     1         89.9                                            Example 2    Rat     1         71.9                                            Example 3    Mouse   0.3       99.9                                            Example 4    Mouse   0.3       36.3                                            Example 5    Mouse   0.3       87.2                                            Example 12   Rat     1         92.9                                            Example 13   Rat     1         77.7                                            Example 14   Rat     0.5       25.4                                            Example 15   Rat     0.5       38.5                                            Example 16   Rat     0.5       43.6                                            Example 18   Rat     0.5       61.4                                            Example 20   Mouse   0.3       99.9                                            Example 22   Mouse   0.3       15.2                                            Reference Example 1                                                                         Rat     0.5       0                                               Reference Example 2                                                                         Rat     0.5       0                                               PMEA         Rat     1         35.5                                            ______________________________________                                     

What is claimed is:
 1. A phosphonate-nucleotide ester compound of the following formula (I): ##STR21## wherein ring A represents ##STR22## wherein R¹ represents halogen, hydroxyl, mercapto, tolylthio or amino; R² represents hydrogen or amino; R³ represents ethyl having one or more fluorine substituents; R⁴ represents ethyl having one or more fluorine substituents; X, Y and Z independently represent methyne or nitrogen atom; or a pharmaceutically acceptable salt thereof.
 2. The compound according to claim 1, wherein R¹ is tolylthio.
 3. The compound according to claim 1, wherein R² is amino.
 4. The compound according to claim 1, wherein R³ is 2,2,2-trifluoroethyl.
 5. The compound according to claim 1, wherein R⁴ is 2,2,2-trifluoroethyl.
 6. The compound according to claim 1, wherein X and Z are nitrogen atoms, X and Y are nitrogen atoms, or X, Y and Z are nitrogen atoms.
 7. A pharmaceutical composition which comprises a compound of claim 1 and a pharmaceutically acceptable carrier. 